The study examined the lexico-semantic choices selected by Cyprian Ekwensi in the construction of the novel Iska. It particularly explored the lexical features and figurative language that gave perceptible meaning to the novel Iska. The researchers employed the content analysis as an analytical tool to unravel the words, codes, figurative language and the meaning derived from the selection of the lexis and language. It was discovered that Cyprian Ekwensi utilized semantic field, word field, compound words, synonyms, local words from indigenous Nigerian languages: Ibo, Hausa and Yoruba to explore his thematic preoccupations. Also, the researchers discovered the use of figurative language in the forms of metaphor, simile, personification oxymoron and repetition in giving clarity and colour to the novel. Cyprian Ekwensi succeeded in capturing the realities in human experience excellently.It was also discovered that the novel bore hallmarks of social-cultural filterings which is typical in modern African prose.