Post-colonial writing is notable for its wide range of language and stylistic variations and deviations, as well as for the numerous topics and subject matter options drawn from actual events and experiences. Post-colonial writing has a unique language and style that blends with its tradition and culture. The status of women in contemporary society has never been favourable throughout history. The status of women has not changed despite social, economic, and cultural advances. Despite gender inequality, the vast majority of women are willing to accept a life of humiliation. To play the roles of wife, mother, and grandparent, they are complacent. Cross-cultural conflict has grown in popularity since the turn of the 20th century. To pursue their goals and objectives, people have begun emigrating to various nations. In comparison to past immigrants from Asia, the Indian immigrant community in America has had a qualitatively different experience. People from all across the world now love America. People move here in order to fulfil their ambitions. It is challenging for the migrated people to adapt to the new culture and go through cultural transition. They fight to adapt to the new culture while remaining silent, but in vain. Their emotions are conflicted between a sense of rootlessness and nostalgia. Indian traditional culture places a significant value on the family unit; hence Indian novelists have treated family ties with considerable seriousness. They have covered the subject of the man-woman relationship, which is extremely important in terms of history, sociology, and culture. In light of this, this paper examines the cross-cultural conflict between the characters in Bharati Mukherjee's "Wife".